Search on:
INTEGRIN ALPHAVBETA3
Descriptors Found:
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DeCS
Descriptor
English
:
Integrin alphaVbeta3
Descriptor
Spanish
:
Integrina alfaVbeta3
Descriptor
Portuguese
:
Integrina alfaVbeta3
Tree Number:
D12.776.395.550.625.439
D12.776.543.550.625.439
D12.776.543.750.705.408.460.870.500
D12.776.543.750.705.675.541
Definition
English
:
An integrin that binds to a variety of
plasma
and
extracellular matrix proteins
containing the conserved RGD
amino acid sequence
and modulates
cell adhesion
.
Integrin alphavbeta3
is highly expressed in
OSTEOCLASTS
where it may play role in
BONE RESORPTION
. It is also abundant in
vascular smooth muscle
and
endothelial cells
, and in some tumor cells, where it is involved in angiogenesis and cell
migration
. Although often referred to as the
vitronectin
receptor there is more than one receptor for
vitronectin
(RECEPTORS,
VITRONECTIN
).
Indexing Annotation
English
:
do not confuse X ref
VITRONECTIN
RECEPTOR with
VITRONECTIN
RECEPTORS
History Note
English
:
2003; use RECEPTORS, VITRONECTIN 1996-2002
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
37452
Unique Identifier:
D039302
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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